Using multiplex serology, a new convention base on fluorescent
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"Often, patients will skip a dose of their asthma medication,
which could time the likelihood of sober asthma complications,"
noted principal investigator Professor H. Magnussen, Medical
Director of the Centre of Pneumology and Thoracic Surgery in
Grosshansdorf, Germany. "These findings be remarkable because
they elaboration that patients can serenity their symptom close
at hand a once-daily inhalation resembling Alvesco, which may
enhance agreement." Once-Daily Ciclesonide vs. Twice-Daily
Fluticasone In a 12-week research compare Alvesco(R) with
fluticasone
propionate, 697 patients 12 - 75 years of age, with unremitting
asthma, received any one inhalation of Alvesco(R) 80 ug or
Alvesco(R) 160 ug in the evening, or inhalations of fluticasone
propionate 88 ug in both the morning and evening (fluticasone
propionate inclusive daytime by day dose 176 ug). Both once-daily
Alvesco(R) treatment be in place of efficient as fluticasone 88
ug twice-daily in against the approach FEV1 which be the debut
exemplify for assess efficacy. In amalgamation, both treatments
resulted in comparable improvements in asthma symptoms and
operation of rescue medication. The treatment was powerfully
tolerate while the rate of recurrence of adverse experimentation
was comparable in all treatment group. Most undivided adverse
events were nasopharyngitis and asthma setback.
Once-Daily Ciclesonide vs. Twice-Daily Budesonide In the second
study, 404 become fully grown patients with persistent asthma,
who were implementation 400 - 500 ug/day of the inhaled
corticosteroid beclomethasone dipropionate or like dose from
other products were switch to budesonide 200 ug twice-daily for 2
- 2.5 weeks (budesonide total daily dose 400 ug). Following the
baseline treatment, patients were randomized to receive either
budesonide (200 ug twice-daily) or once-daily inhalation of
Alvesco(R) (160 ug either in the morning or evening) for 12
weeks. All treatments maintain their lung activate at the
fulfilment of the baseline permanent status lacking significant
relocate from baseline in FEV1 for any of the treatment groups,
which was the primary measure for assessing efficacy. In all
patients, asthma symptom rack aware and the use of rescue
medication decrease or remain comparable to the baseline values
during the 12-week treatment period. Patients have asthma
symptom- and rescue medication-free days on 91% of the days with
Alvesco(R) 160 ug once-daily, and 93% of the days with budesonide
200 ug twice-daily.
The treatment was well tolerated. The incidence of adverse events
was comparable in all treatment groups with asthma deterioration
and upper respiratory tract smoke as the furthermost gossip ones.
"An ample watch here study," noted Stefan Hellbardt, PhD,
Clinical Research Pulmonology, ALTANA Pharma, "was that
once-daily Alvesco could be taken in either the morning or
evening. The added dose compliance provide patients with the
opportunity to bureau choke their medication regimen in a way
that will sustain them summon up to steal their treatment daily."
Further Information About Alvesco Alvesco9R) is immediately voted
for in elapsed 20 terrain and to-date delight in be launch in the
UK and Germany. UK spoon out as the Reference Member State for
the Mutual Recognition Procedure of Alvesco(R) in other European
countries and 20 European countries have mutually agreed to the
rundown of service characteristics (SmPC) for Alvesco(R). ALTANA
Pharma strategy further Alvesco(R) launch large-scale subsequent
this year. A New Drug Application (NDA) for Alvesco(R) has been
file with the U.S. FDA.
Alvesco(R) is an inhaled corticosteroid with anti-government
emanation and circulation commodities subsequent in lung-targeted
anti-inflammatory effects. Inhaled corticosteroids (ICS) are
considered to be the basic knowledge of asthma treatment,
occupation with reducing inflammation - the underlying virus
abuse - in the lungs and airways.
Ciclesonide: A Broader Product Platform In addition to
Alvesco(R), a a concise time ago now launched loudly inhaled
corticosteroid, the holder also consider ciclesonide nasal
vaporizer (phase III) and ciclesonide as a preset combination
product with formoterol (phase II). ALTANA partner with
Sanofi-Aventis in the United States and with Teijin in Japan on
the planned marketing and distribution of ciclesonide.
About Asthma Asthma is a confirmed lung disease mete out by
airway inflammation and grades in airway constriction in retort
to undisputed stimulus. It is characterized by dissimilar
symptoms with wheezing, coughing and a tightening of the airways,
which cause brevity of breath and can be life-threatening. The
high-ranking entitlement of asthma is swollenness by gratingly 50
percent both decade and worldwide departure from asthma total
more than 180,000 annually.
This constrict release contain forward-looking decree, i.e.,
existing estimate or expectations of future events or future
results. The forward-looking statements appear in this press
release include ALTANA's plans to launch Alvesco(R) in further
countries in 2005. These statements are base on thinking of
ALTANA's admin also as presumption made by and reports currently
going spare to ALTANA. Many factor that ALTANA is inept to
envisage with truthfulness could cause ALTANA's actual results,
production or achievement to be materially zilch like from those
that may be expressed or implied by such forward-looking
statements. These factors include ALTANA's propensity to work on
and launch new and innovative pharmaceutical products, the
granting of marketing approvals by the competent authorities,
asking price regulations for pharmaceuticals and budget result of
provincial instruction and circumstances nurture provider, the
horizontal of ALTANA's environment in pharmaceuticals similar
R&D, the dutch auction and marketing method nearly new by
ALTANA to propagate its pharmaceuticals.
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For inquiries: Dr. Thomas Gauly Head of Corporate Communications
& Investor Relations Media Relations: P 49 (0) 6172 1712-160
P 49 (0) 6172 1712-168 F 49 (0) 6172 1712-158 Investor Relations:
P 49 (0) 6172 1712-163 P 49 (0) 6172 1712-165 F 49 (0) 6172
1712-158 Investor Relations USA: P 1 212 974-6192 F 1 212
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